Paradoxical Activation of Entheseal Myeloid Cells by <scp>JAK1</scp> and Tyk2 Inhibitors via Interleukin‐10 Antagonism
These findings help explain the emergent efficacy of Tyk2 blockade in SpA spectrum-related arthritis that is not IL-10 dependent but indicates why such strategies may not be a panacea for SpA spectrum disorder-related intestinal inflammation.
Authors
- Almas Khan (ORCID: https://orcid.org/0000-0002-7916-6219)
- Kerem Abacar (ORCID: https://orcid.org/0000-0002-7668-7924)
- Chi Huey Wong (ORCID: https://orcid.org/0000-0003-2108-1615)
- Dennis McGonagle (ORCID: https://orcid.org/0000-0001-7428-0146)
- Tracy R. McMillan
- Mark Harland (ORCID: https://orcid.org/0000-0002-0077-9742)
- Ala Altaie (ORCID: https://orcid.org/0000-0002-9203-1490)
- Sami Giryes (ORCID: https://orcid.org/0000-0002-4105-3550)
- Tom Macleod (ORCID: https://orcid.org/0000-0002-7903-2990)
- Vishal Borse
- Charlie Bridgewood (ORCID: https://orcid.org/0000-0001-6797-4633)
- Robert Dunsmuir (ORCID: https://orcid.org/0000-0002-1547-5055)
- N. McDermott
- Abhay Rao
- Peter Loughenbery
Institutions
- University of Leeds (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Rambam Health Care Campus (IL)
- National Institute for Health and Care Research (GB)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1002/art.43210
- Citations
- 3
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- KU Leuven