Potential Value of Plasma-Based Biomarkers for Prediction of Episodic Memory Performance and Identification of Individuals with Amnestic Mild Cognitive Impairment
We provided support to the use of plasma total-tau and NfL as simple biomarkers to predict the severity of episodic memory deficit for individual aMCI patients and aMCI progression, and further demonstrated that the combination of plasma <i>Aβ</i>42/<i>Aβ</i>40, hippocampal/parahippocampal volume, and MMSE score could serve as an integrated screening tool to select aMCI individuals.
Authors
- Mengxue Wang (ORCID: https://orcid.org/0000-0002-0756-7427)
- Yachen Shi (ORCID: https://orcid.org/0000-0003-2241-9227)
- Chunming Xie (ORCID: https://orcid.org/0000-0002-5978-9689)
- Zhengsheng Zhang (ORCID: https://orcid.org/0000-0002-3283-3272)
- Hao Shu
- Zan Wang (ORCID: https://orcid.org/0000-0003-4770-2803)
- Qingguo Ren (ORCID: https://orcid.org/0000-0001-9758-5268)
Institutions
- Zhongda Hospital Southeast University (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Neuropsychiatric Disease and Treatment
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/ndt.s516476
- Primary Topic
- Cognitive Functions and Memory
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province