Causal relationship between chronic kidney disease, renal function, and venous thromboembolism: a bidirectional Mendelian randomization study
This MR analysis provides evidence that elevated serum creatinine is associated with a higher risk of VTE and PE, while reduced eGFR may be a potential risk factor for VTE and its subtypes. These findings highlight the need for proactive monitoring and preventive strategies in individuals with impaired renal function. Further studies are warranted to confirm these associations and explore underlying mechanisms.
Authors
- Xiqian Xing (ORCID: https://orcid.org/0000-0002-5359-1778)
- Yue Xu (ORCID: https://orcid.org/0000-0001-5524-1977)
- Jiao Yang (ORCID: https://orcid.org/0000-0002-6202-5022)
- Rongping Yang (ORCID: https://orcid.org/0000-0002-5722-1790)
- Xifeng Zhang (ORCID: https://orcid.org/0000-0002-4337-2168)
- Huilin He (ORCID: https://orcid.org/0000-0003-2336-8097)
- Shuanglan Xu (ORCID: https://orcid.org/0000-0002-4333-3804)
- Qian Liu (ORCID: https://orcid.org/0000-0003-3758-3054)
- Linna Chen
Institutions
- Yunnan University (CN)
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Yunnan Provincial Department of Education (CN)
Publication Details
- Journal
- Renal Failure
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1080/0886022x.2025.2496803
- Citations
- 3
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- National Natural Science Foundation of China