Ability of SPP1 to Alleviate Post‐Intracerebral Hemorrhage Ferroptosis via Nrf2/HO1 Pathway
This study provides novel evidence for SPP1/OPN as a key modulator of ferroptosis in ICH, highlighting its potential as a therapeutic target. By enhancing iron homeostasis and mitigating oxidative stress, OPN offers a promising strategy for improving outcomes in ICH patients.
Authors
- Yilu Li (ORCID: https://orcid.org/0000-0002-2642-4579)
- Zhanglei Mu (ORCID: https://orcid.org/0000-0003-3470-608X)
- Xudong Zhao (ORCID: https://orcid.org/0000-0002-3568-1649)
- Pengpeng Li (ORCID: https://orcid.org/0000-0001-6653-7183)
- Yating Zhang (ORCID: https://orcid.org/0000-0002-6927-8452)
- Wenhui Yang (ORCID: https://orcid.org/0009-0007-6235-2043)
- Yangyang Gao (ORCID: https://orcid.org/0009-0004-1483-2374)
- J Tian (ORCID: https://orcid.org/0009-0003-9813-5017)
- Zhongbin Tao
Institutions
- Jiangnan University (CN)
- Nantong University (CN)
- Wuxi No.2 People's Hospital (CN)
- Ningxia Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/brb3.70493
- Citations
- 6
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 9.11
Funders
- National Natural Science Foundation of China