Predictors of atypical language lateralization in focal epilepsy: A mega‐analysis of <scp>fMRI</scp> evidence

Consistent with theories of language plasticity, we demonstrated a robust effect of early acquired left hemisphere injury on language lateralization. There was also a subtle effect of duration of epilepsy, perhaps reflecting increasing bilaterality with age in adulthood. The association between left/ambidextrous handedness and atypical language lateralization in the left and right hemisphere groups likely reflects both genetic and epilepsy-associated effects. The total number of predictors identified for an individual could serve as an indication for presurgical language fMRI, when surgical management is considered.

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Publication Details

Journal
Epilepsia
Published
2025-05-05
DOI
https://doi.org/10.1111/epi.18422
Citations
1
Primary Topic
Hemispheric Asymmetry in Neuroscience
Type
article
Field-Weighted Citation Impact
1.43

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Predictors of atypical language lateralization in focal epilepsy: A mega‐analysis of fMRI evidence

William D. Gaillard, Jennifer Murphy, Torsten Baldeweg, Frédérique Liégeois et al.
1 citations
Epilepsia
Hemispheric Asymmetry in Neuroscience
1.43
article

Predictors of atypical language lateralization in focal epilepsy: A mega‐analysis of fMRI evidence

William D. Gaillard, Jennifer Murphy, Torsten Baldeweg, Frédérique Liégeois, Leigh N. Sepeta, Freya Prentice, Madison M. Berl, Maria H. Eriksson, Lara Chehabeddine
article en
1 citations

Abstract

Consistent with theories of language plasticity, we demonstrated a robust effect of early acquired left hemisphere injury on language lateralization. There was also a subtle effect of duration of epilepsy, perhaps reflecting increasing bilaterality with age in adulthood. The association between left/ambidextrous handedness and atypical language lateralization in the left and right hemisphere groups likely reflects both genetic and epilepsy-associated effects. The total number of predictors identified for an individual could serve as an indication for presurgical language fMRI, when surgical management is considered.

EpilepsiaVol. 66(8)
George Washington University Hospital (US), Children's National (US), George Washington University (US), Great Ormond Street Hospital (GB), Hospital for Sick Children (CA), University of Surrey (GB), SickKids Foundation (CA), University College London (GB), American University of Beirut (LB)
Children's National Hospital, National Institute for Health and Care Research, Sigrid Juséliuksen Säätiö, NIHR Great Ormond Street Hospital Biomedical Research Centre, National Institute of Neurological Disorders and Stroke
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Openalex Percentile: Top 20%
Hemispheric Asymmetry in Neuroscience
1.43
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Predictors of atypical language lateralization in focal epilepsy: A mega‐analysis of <scp>fMRI</scp> evidence — William D. Gaillard, Jennifer Murphy, et al. · Epilepsia (2025) | TGRS Research Map | TGRS