Changes in Nucleolar Activity Under Conditions of Microsatellite Instability in the Uterine Mucosa in Precancer and Endometrial Cancer

Introduction. The study of histochemical features of the proliferative activity of the endometrium in conditions of microsatellite instability in the endometrium in women with precancerous damage to the mucous membrane is of clinical interest for determining the prognosis of malignancy and tactics of managing patients with this pathology. The aim of the study was to analyze the state of the nucleolar organizer system in conditions of microsatellite instability in the uterine mucosa in patients with precancer and endometrial cancer in a comparative aspect. Materials and methods. A one-stage non-randomized retrospective study was performed using histological, immunohistochemical and statistical methods. Results. An increase in the activity of nucleolar organizers was established in microsatellite instability, indicating an increase in protein-synthetic activity in cells and, as a consequence, the proliferative potential of glandular epithelial cells and endometrial stromal cells in its hyperplasia and carcinoma. Conclusion. The obtained results can be used as an additional factor in determining the tactics of managing patients with precancer and endometrial cancer.