Janus kinase inhibitors enhance prostanoid biosynthesis in human whole blood in vitro: implications for cardiovascular side effects and prevention strategies
The enhanced biosynthesis of TXA<sub>2</sub> in platelets, with a minor contribution from leukocytes, may contribute to the increased cardiovascular risk associated with JAKis. Low-dose aspirin may offer a protective effect, warranting further investigations.
Authors
- Vilija Oke (ORCID: https://orcid.org/0000-0002-1834-2688)
- M. De Vries
- Iva Gunnarsson (ORCID: https://orcid.org/0000-0002-4514-7706)
- Helena Idborg (ORCID: https://orcid.org/0000-0003-4041-4729)
- Marika Kvarnström (ORCID: https://orcid.org/0000-0002-4948-8380)
- Stefania Tacconelli (ORCID: https://orcid.org/0000-0003-4907-1822)
- Patrizia Di Gregorio (ORCID: https://orcid.org/0009-0006-0771-8404)
- Paola Patrignani (ORCID: https://orcid.org/0000-0003-1419-2691)
- Sabreen Alabbasi
- Alessandra De Michele
- Per‐Johan Jakobsson
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- University of Chieti-Pescara (IT)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1016/j.ard.2025.03.014
- Citations
- 4
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Queen Mary University of London
- Cancerfonden
- Stockholms Läns Landsting
- Vetenskapsrådet
- Stiftelsen Konung Gustaf V:s 80-årsfond
- Reumatikerförbundet
- Ulla och Gustaf af Ugglas Stiftelse