Profiling of Anti‐FVIII Antibodies in Acquired Haemophilia A: ‘Insights into Domain Specificity, Isotype Variability, and Clinical Correlations’
Anti-FVIII antibody profiling reveals distinct patterns in AHA, with IgG<sub>4</sub> linked to higher inhibitor levels. The C1C2 domain specificity of the anti-FVIII antibodies suggests a potential role of this FVIII domain in the immunopathology of AHA patients, warranting further investigation to improve prognostic tools.
Authors
- Isabell Matuschek (ORCID: https://orcid.org/0000-0002-8681-777X)
- Ann‐Cristin Berkemeier
- T. Albert (ORCID: https://orcid.org/0000-0002-0102-2792)
- Behnaz Pezeshkpoor (ORCID: https://orcid.org/0000-0002-4796-3424)
- Johannes Oldenburg (ORCID: https://orcid.org/0000-0002-1585-4100)
- Katrin Hartlieb
- Natascha Marquardt
Institutions
- University of Bonn (DE)
- University Hospital Bonn (DE)
Publication Details
- Journal
- Haemophilia
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1111/hae.70056
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00