Design, Synthesis, and Biological Evaluation of a Novel Series of Thiazolidinediones as Dual GSK-3β and Tau Aggregation Inhibitors
Overall, the study identified three promising TZDs with potential as inhibitors of GSK-3β and tau proteins, highlighting compound 5l as particularly effective in stabilizing GSK- 3β and disrupting tau aggregation.
Authors
- Mojgan Nejabat (ORCID: https://orcid.org/0000-0001-8638-4989)
- Somaieh Soltani (ORCID: https://orcid.org/0000-0002-0102-2960)
- Mohamad Reza Kalani (ORCID: https://orcid.org/0000-0002-8756-1200)
- Khalil Abnous (ORCID: https://orcid.org/0000-0001-6314-0164)
- Farzin Hadizadeh (ORCID: https://orcid.org/0000-0002-7680-8191)
- Seyed Mohammad Taghdisi (ORCID: https://orcid.org/0000-0001-9836-2189)
- Zahra Abdollahi (ORCID: https://orcid.org/0000-0002-9111-5959)
Institutions
- University of Illinois Urbana-Champaign (US)
- Tabriz University of Medical Sciences (IR)
- Mashhad University of Medical Sciences (IR)
- Golestan University (IR)
- Biotechnology Research Center (IR)
- Golestan University of Medical Sciences (IR)
Publication Details
- Journal
- Medicinal Chemistry
- Published
- 2025-05-05
- DOI
- https://doi.org/10.2174/0115734064369119250413021648
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00