Ranolazine: An Established Anti-anginal Drug with Emerging Antidiabetic Potential Supported by Preclinical and Clinical Evidence

A novel approach for treating T2DM could involve selective Nav1.3 blockers, as ranolazine's unique mechanism of action distinguishes it from other approved antidiabetic medications. Targeting Nav1.3 channels may offer similar glycemic control benefits while minimizing side effects. This strategy could lead to innovative treatments that address both DM management and cardiovascular protection. Further research is needed to evaluate the efficacy and safety of these selective blockers in diabetic patients.