Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and without GBA1 variants
We studied the age- and genetic-related prevalence of CSF alpha-Synuclein seeding and Alzheimer profiles in 188 samples from PD participants without GBA1 variants (PD<sub>wildtype</sub>) and in 129 samples from PD participants with GBA1 variants (PD<sub>GBA1</sub>). While Alzheimer profiles increased with age in PD<sub>wildtype</sub>, it was sparse in PD<sub>GBA1</sub>. Alpha-Synuclein profiles remained stable with age in both cohorts. In PD<sub>wildtype</sub>, combined alpha-Synuclein/Alzheimer profiles were associated with earlier onset of cognitive impairment.
Authors
- Kathrin Brockmann (ORCID: https://orcid.org/0000-0002-7515-8596)
- Milan Zimmermann (ORCID: https://orcid.org/0000-0001-7066-7749)
- Simone Baiardi (ORCID: https://orcid.org/0000-0002-7702-7856)
- Stefanie Lerche (ORCID: https://orcid.org/0000-0002-5508-004X)
- Piero Parchi (ORCID: https://orcid.org/0000-0002-9444-9524)
- Marcello Rossi (ORCID: https://orcid.org/0000-0002-8125-6571)
- Angela Mammana (ORCID: https://orcid.org/0000-0002-3306-8365)
- Claudia Schulte (ORCID: https://orcid.org/0000-0003-4006-1265)
- Benjamin Röeben (ORCID: https://orcid.org/0000-0002-4905-8698)
- Ann‐Kathrin Hauser (ORCID: https://orcid.org/0009-0003-7848-5722)
- Christian Deuschle (ORCID: https://orcid.org/0000-0001-5571-7293)
- Isabel Wurster (ORCID: https://orcid.org/0000-0003-0157-5722)
Institutions
- German Center for Neurodegenerative Diseases (DE)
- Centre for Movement Disorders (CA)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Hertie Institute for Clinical Brain Research (DE)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Bologna (IT)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1038/s41531-025-00978-1
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Eberhard Karls Universität Tübingen
- Bundesministerium für Bildung und Forschung
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Regione Emilia-Romagna