The Role of Serum Beta-Trace Protein in the Diagnosis and Prognosis of Sepsis Patients in the Emergency Department

Aim: This study aimed to evaluate the diagnostic and prognostic significance of serum beta-trace protein (BTP) levels in patients diagnosed with sepsis in the emergency department. Materials and Methods:This prospective, single-center, observational clinical study was conducted in the emergency department and intensive care unit of a tertiary hospital.A total of 104 sepsis patients and 48 healthy adult volunteers who presented to the emergency department between April 2015 and October 2015 were included.Blood samples were collected on days 1 and 3, and BTP levels were measured using the ELISA method.Statistical analyses were performed using SPSS 22.0.Results: BTP levels were significantly higher in sepsis patients compared to the control group (p=0.013).However, no significant difference was observed between day 1 and day 3 BTP levels (p=0.119).When categorized by sepsis severity, BTP levels did not correlate with disease severity (p>0.05).Additionally, no significant association was found between BTP levels and mortality (p=0.651). Conclusion:BTP may serve as a potential biomarker for sepsis diagnosis, but it is not a reliable indicator of disease severity or prognosis.Further large-scale studies are needed.