Protective effects of Nippostrongylus brasiliensis-derived uridine via the apical sodium-dependent bile acid transporter in a mouse model of TNBS-induced inflammatory bowel disease
The current study has illustrated that uridine is capable of exerting potential therapeutic and anti-inflammatory effects on Inflammatory Bowel Disease (IBD) by modulating <i>slc10a2</i>. These findings could offer a novel therapeutic target for the intervention of IBD.
Authors
- Hongxia Bai
- Xin Ding (ORCID: https://orcid.org/0000-0001-5749-867X)
- Qiang Wang (ORCID: https://orcid.org/0000-0003-1090-2174)
- Qiang Zhang (ORCID: https://orcid.org/0000-0002-4285-7964)
- Bei Zhang (ORCID: https://orcid.org/0000-0002-7797-7616)
- Yang Dai (ORCID: https://orcid.org/0000-0003-1489-9080)
- Yuying Chen (ORCID: https://orcid.org/0000-0001-9091-2051)
- Jiakai Yao
- Caiyi Yuan
Institutions
- Guangzhou Center for Disease Control and Prevention (CN)
- Jiangsu Institute of Parasitic Diseases (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1600838
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- Wuxi Health and Family Planning Commission