Predictors of response to burosumab in adults with X-linked hypophosphatemia: real-world data from an Italian cohort
Burosumab effectively increased serum phosphate levels and improved clinical outcomes in a real-world setting, particularly in patients with more substantial increases in serum phosphate levels. Baseline serum phosphate, PTH, and FGF23 levels predicted response, helping tailor treatment strategies and improve long-term patient management.
Authors
- Maria Michela D’Alessandro
- Elena Campello (ORCID: https://orcid.org/0000-0002-0377-3741)
- Michele Cannito (ORCID: https://orcid.org/0009-0007-9208-0632)
- Paolo Simioni (ORCID: https://orcid.org/0000-0002-6744-383X)
- Marta Zampogna
- Marco Onofrio Torres (ORCID: https://orcid.org/0009-0004-1426-1452)
- Gaetana Cerbone
- Maria Fusaro (ORCID: https://orcid.org/0000-0001-9478-4851)
- Gemma Marcucci (ORCID: https://orcid.org/0000-0003-0579-0542)
- Francesca Guidolin (ORCID: https://orcid.org/0000-0002-5956-7007)
- Giuseppe Vezzoli (ORCID: https://orcid.org/0000-0003-4481-5693)
- Maria Luisa Brandi (ORCID: https://orcid.org/0000-0002-8741-0592)
- Valentina Camozzi (ORCID: https://orcid.org/0000-0002-1634-951X)
- Gaetano Paride Arcidiacono (ORCID: https://orcid.org/0000-0003-0409-4449)
- Sandro Giannini (ORCID: https://orcid.org/0000-0003-0796-9749)
- Mor Peleg Falb (ORCID: https://orcid.org/0009-0006-9413-3710)
- Corrado Vitale (ORCID: https://orcid.org/0000-0002-2892-3726)
- Alberta Cecchinato
- Cristina Eller-Vainicher
- Giovanni Tripepi
- Martina Zaninotto
- Antonio Aversa
- Giuseppe Girasole
- Mario Plebani
- Stefania Sella (ORCID: https://orcid.org/0000-0002-8645-4067)
- Martin Diogo
Institutions
- University of Padua (IT)
- Vita-Salute San Raffaele University (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Magna Graecia University (IT)
- Istituto di Fisiologia Clinica (IT)
- Azienda Ospedaliera S.Giuseppe Moscati (IT)
- Fondazione Europea Ricerca Biomedica (IT)
- A. O. Ordine Mauriziano di Torino (IT)
- Azienda di Rilievo Nazionale ed Alta Specializzazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
- Villa Torri Hospital (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Florence (IT)
Publication Details
- Journal
- Journal of Endocrinological Investigation
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1007/s40618-025-02596-3
- Citations
- 2
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Università degli Studi di Padova