Moxibustion regulates KDM4D expression and modulates lipid metabolism to inhibit tumor proliferation in CAC mice
Moxibustion inhibited the proliferation of colon tumors in CAC mice, inhibited the activation of the tumor-promoting signaling pathway KDM4D/β-Catenin, and improved lipid metabolism disorders in the colon, thus providing a promising strategy for the clinical adjuvant treatment of colorectal cancer.
Authors
- Hongxiao Xu
- Guona Li (ORCID: https://orcid.org/0000-0002-9984-7759)
- Huangan Wu (ORCID: https://orcid.org/0000-0003-1725-6881)
- Muen Gu
- Hongsheng Dong (ORCID: https://orcid.org/0000-0002-6683-4441)
- Han-Xiao Zhang (ORCID: https://orcid.org/0000-0001-6244-4617)
- Kunshan Li (ORCID: https://orcid.org/0000-0002-0316-1753)
- Jindan Ma
- Yaying Lin
- Luyi Wu (ORCID: https://orcid.org/0000-0001-8888-1698)
- Yan Huang (ORCID: https://orcid.org/0000-0002-5588-0274)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine (CN)
- Shanghai Research Center for Acupuncture and Meridians (CN)
- Yueyang Hospital (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1186/s12935-025-03798-8
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- State Administration of Traditional Chinese Medicine of the People's Republic of China
- Shanghai Clinical Research Center