Tumor Hypoxia and CD8<sup>+</sup> T‐Cell Infiltration in Patients With Advanced Laryngeal Cancer
CAIX staining correlates with reduced CD8<sup>+</sup> T-cell infiltration in patients with advanced laryngeal squamous cell carcinoma undergoing bioselection. The combination CAIX/TIL category is associated with the likelihood and degree of response to induction. The utility of CAIX status and other combination immune and hypoxia signatures as a biomarker of induction response and survival merits prospective evaluation.
Authors
- Scott A. McLean (ORCID: https://orcid.org/0000-0002-1884-6632)
- Chaz L. Stucken (ORCID: https://orcid.org/0000-0003-1448-3376)
- Francis P. Worden (ORCID: https://orcid.org/0000-0002-6632-4951)
- Joshua D. Smith (ORCID: https://orcid.org/0000-0002-2076-7589)
- Keith Casper (ORCID: https://orcid.org/0000-0003-2878-3863)
- Kelly M. Malloy (ORCID: https://orcid.org/0000-0002-0337-9293)
- Mark E. Prince (ORCID: https://orcid.org/0000-0002-1120-9008)
- David Forner (ORCID: https://orcid.org/0000-0002-1014-3545)
- Pratyusha Yalamanchi (ORCID: https://orcid.org/0000-0003-0776-3759)
- Paul Swiecicki (ORCID: https://orcid.org/0000-0003-2286-3555)
- Andrew G. Shuman (ORCID: https://orcid.org/0000-0002-9305-7860)
- Matthew E. Spector (ORCID: https://orcid.org/0000-0001-7646-6075)
- Michelle Mierzwa (ORCID: https://orcid.org/0000-0002-3923-9970)
- Elizabeth Gensterblum‐Miller (ORCID: https://orcid.org/0000-0002-8714-1257)
- Jennifer Shah (ORCID: https://orcid.org/0000-0002-3847-8865)
- Marisa R. Buchakjian (ORCID: https://orcid.org/0000-0001-8261-1566)
- J. Chad Brenner (ORCID: https://orcid.org/0000-0003-3238-1111)
- Steven Bennett Chinn (ORCID: https://orcid.org/0000-0003-4282-0640)
- Molly E. Heft Neal (ORCID: https://orcid.org/0000-0002-8813-5537)
Institutions
- University of Michigan (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Otolaryngology
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1002/ohn.1291
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs