Gout and <scp>NLRP3</scp> Inflammasome Biology
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilization, and self-resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal-induced inflammation is reviewed in detail. Treatment strategies for gout are outlined in the context of the mechanisms of NLRP3 inflammasome-mediated acute inflammation.
Authors
- Raewyn C. Poulsen (ORCID: https://orcid.org/0000-0002-3788-6410)
- Nicola Dalbeth (ORCID: https://orcid.org/0000-0003-4632-4476)
Institutions
- University of Auckland (NZ)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1002/art.43215
- Citations
- 8
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.45