Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies
This study identified 14 genes linked to LACD in knockout mice, 12 of which are novel in corneal biology. These genes may serve as potential therapeutic targets for treating corneal diseases in aging human populations.
Authors
- Michel J. Roux (ORCID: https://orcid.org/0000-0002-5812-5215)
- Haerim Kim (ORCID: https://orcid.org/0000-0003-4156-3988)
- Benjamin A. Yang (ORCID: https://orcid.org/0000-0001-7412-6261)
- Martin Hrabě de Angelis (ORCID: https://orcid.org/0000-0002-7898-2353)
- Helmut Fuchs (ORCID: https://orcid.org/0000-0002-5143-2677)
- Atsushi Yoshiki (ORCID: https://orcid.org/0000-0002-9450-5151)
- Fabrice Riet
- Lauryl M. J. Nutter (ORCID: https://orcid.org/0000-0001-9619-146X)
- Yeon Kyung Kang
- Ann M. Flenniken (ORCID: https://orcid.org/0000-0003-1892-6154)
- Mohammad Eskandarian
- David J. Adams (ORCID: https://orcid.org/0000-0002-7030-2288)
- Wolfgang Wurst (ORCID: https://orcid.org/0000-0003-4422-7410)
- Takanori Amano (ORCID: https://orcid.org/0000-0002-0213-4745)
- Louise Lanoue (ORCID: https://orcid.org/0000-0003-2779-0391)
- Soo Young Cho (ORCID: https://orcid.org/0000-0002-2960-9878)
- Jan Procházka (ORCID: https://orcid.org/0000-0003-4675-8995)
- Jin Sun (ORCID: https://orcid.org/0000-0001-8525-8796)
- Zorana Berberovic
- Hyuna Noh (ORCID: https://orcid.org/0000-0003-4806-6730)
- Miles Joseph Raishbrook
- Ki-Hoan Nam
- Brian C. Leonard (ORCID: https://orcid.org/0000-0003-2080-8480)
- Marcela Pálková
- Je Kyung Seong (ORCID: https://orcid.org/0000-0003-1177-6958)
- Thao Vo (ORCID: https://orcid.org/0009-0005-5439-8354)
- Hiroshi Masuya (ORCID: https://orcid.org/0000-0002-3392-466X)
- Oana V. Amarie (ORCID: https://orcid.org/0000-0003-1705-6812)
- Samantha Burrill
- Ala Moshiri (ORCID: https://orcid.org/0000-0002-4277-8094)
- Jason Salazar
- Toshihiko Shiroishi (ORCID: https://orcid.org/0000-0003-0535-2016)
- Hae-Sol Shin
- Colin McKerlie (ORCID: https://orcid.org/0000-0002-2232-0967)
- Hamid Méziane (ORCID: https://orcid.org/0000-0002-4704-7055)
- Yann Hérault (ORCID: https://orcid.org/0000-0001-7049-6900)
- Abigail D’Souza (ORCID: https://orcid.org/0000-0002-9748-5088)
- Mohammed Selloum (ORCID: https://orcid.org/0000-0003-4057-3519)
- Lynette Bower
- Karen L. Svenson (ORCID: https://orcid.org/0000-0002-7928-1911)
- Heather Tolentino
- Kyoung Yul Seo (ORCID: https://orcid.org/0000-0002-9855-1980)
- Masaru Tamura (ORCID: https://orcid.org/0000-0001-9488-8749)
- Steve D. M. Brown (ORCID: https://orcid.org/0000-0002-0617-4824)
- Radislav Sedlacek
- Sara Wells
- Michelle Stewart
- Russell Joynson
- Sharon Clementson-Mobbs
- Valerie Gailus-Durner
- K. C. Kent Lloyd
- Andrew Briere
Institutions
- Mount Sinai Hospital (CA)
- Centre National de la Recherche Scientifique (FR)
- Seoul National University (KR)
- Inserm (FR)
- University of Toronto (CA)
- Yonsei University (KR)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Touro University California (US)
- Hospital for Sick Children (CA)
- Wellcome Sanger Institute (GB)
- Helmholtz Zentrum München (DE)
- Mary Lyon Centre at MRC Harwell (GB)
- Institut de génétique et de biologie moléculaire et cellulaire (FR)
- RIKEN BioResource Research Center (JP)
- Jackson Laboratory (US)
- Phénotypage et ingénierie précliniques des systèmes d’organismes modèles (FR)
- Sinai Health System (CA)
- Czech Academy of Sciences, Institute of Molecular Genetics (CZ)
- SickKids Foundation (CA)
- Toronto Centre for Phenogenomics (CA)
- California Northstate University (US)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- Hanyang University (KR)
- Technical University of Munich (DE)
- Université de Strasbourg (FR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- University of California, Davis (US)
- Medical Research Council (GB)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1167/iovs.66.5.7
- Citations
- 1
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Genome Canada
- Ontario Genomics
- INFRAFRONTIER
- Government of Canada
- Akademie Věd České Republiky
- National Institutes of Health
- National Center for Advancing Translational Sciences