Localized Microrobotic Delivery of Enzyme‐Responsive Hydrogel‐Immobilized Therapeutics to Suppress Triple‐Negative Breast Cancer (Small 18/2025)
Breast Cancer In article number 2408813, Meysam Keshavarz, Guang-Zhong Yang, and co-workers present a microrobotic platform for the localized delivery of enzyme-responsive hydrogels, designed to release chemotherapeutics within the tumor microenvironment. Utilizing magnetic actuation for precise localization, this system enables sustained drug release, achieving significant tumor reduction and metastasis suppression in a murine model of triple-negative breast cancer, underscoring its potential for broader oncological applications.
Authors
- Meysam Keshavarz (ORCID: https://orcid.org/0000-0002-6813-4860)
- Bing Han (ORCID: https://orcid.org/0000-0001-9763-0372)
- Ali Anıl Demirçalı (ORCID: https://orcid.org/0000-0002-3545-3654)
- Guang‐Zhong Yang (ORCID: https://orcid.org/0000-0003-4060-4020)
- M. Tian (ORCID: https://orcid.org/0009-0007-0573-0263)
Institutions
- Shanghai Jiao Tong University (CN)
- Imperial College London (GB)
Publication Details
- Journal
- Small
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/smll.202570142
- Primary Topic
- Micro and Nano Robotics
- Type
- article
- Field-Weighted Citation Impact
- 0.00