Comparative Efficacy of Interleukin-7 and -15 Blockade in Alleviating Experimental Chronic Uveitis and Suppressing Pathogenic Memory CD4<sup>+</sup> T Cells
Our proof-of-concept study demonstrates that blocking IL-7 or IL-15 leads to specific depletion of the uveitogenic memory CD4+ T cells and disruption of disease chronicity in uveitis.
Authors
- Rachel M. Huckfeldt (ORCID: https://orcid.org/0000-0002-9220-2261)
- Yihe Chen (ORCID: https://orcid.org/0000-0002-2336-6182)
- Maryam Shayan (ORCID: https://orcid.org/0000-0001-6881-3436)
- Qiurong Zhu
Institutions
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- Smith-Kettlewell Eye Research Institute (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1167/iovs.66.5.9
- Citations
- 2
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 3.41
Funders
- Massachusetts Eye and Ear
- National Institutes of Health