Radiomic Analysis of Striatal [18F]FDOPA PET Imaging in Patients with Psychosis for the Identification of Antipsychotic Response
Radiomic analysis of [<sup>18</sup>F]FDOPA PET supports its use as a biomarker for assessing antipsychotic efficacy in schizophrenia, highlighting differential striatal tracer uptake based on patient response. While it provides modest classification improvements over standard imaging, further validation in larger datasets and integration with multivariate classification algorithms are needed.
Authors
- Oliver Howes (ORCID: https://orcid.org/0000-0002-2928-1972)
- Alessio Giacomel (ORCID: https://orcid.org/0000-0002-7784-2041)
- Sameer Jauhar (ORCID: https://orcid.org/0000-0002-3878-3659)
- Rubaida Easmin
- Andrea Bettinelli (ORCID: https://orcid.org/0000-0002-3979-3285)
- Mattia Veronese (ORCID: https://orcid.org/0000-0003-3562-0683)
- Giovanna Nordio (ORCID: https://orcid.org/0000-0002-7835-2992)
- Steven Williams (ORCID: https://orcid.org/0000-0003-4299-1941)
- Pierluigi Selvaggi (ORCID: https://orcid.org/0000-0001-9069-0700)
- Federico Turkheimer (ORCID: https://orcid.org/0000-0002-3766-3815)
- Astrid Schiulaz
Institutions
- University of Padua (IT)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- Hammersmith Hospital (GB)
- Istituto Oncologico Veneto (IT)
- MRC London Institute of Medical Sciences (GB)
- Imperial College London (GB)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1007/s11307-025-02014-3
- Primary Topic
- Radiomics and Machine Learning in Medical Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Ministero dell’Istruzione, dell’Università e della Ricerca
- NIHR Maudsley Biomedical Research Centre