Isolation and identification of Klebsiella pneumoniae phage ΦK2046: optimizing its antibacterial potential in combination with chlorhexidine
This study, using ΦK2046 as an example, demonstrates the potential of phages to enhance the antibacterial and antibiofilm effects of chlorhexidine and their feasibility in medical device disinfection. This innovative approach not only improves chlorhexidine's disinfecting power but also effectively tackles the issue of reduced susceptibility of K. pneumoniae to chlorhexidine. The research advances the development and application of phage-based disinfectants and lays a foundation for establishing a phage library with adjuvant properties for disinfectants.
Authors
- Jianming Cao (ORCID: https://orcid.org/0000-0002-9968-6721)
- Tieli Zhou (ORCID: https://orcid.org/0000-0002-2171-4710)
- Panjie Hu (ORCID: https://orcid.org/0000-0002-3778-7914)
- Zhexiao Ma
- Ying Zhang (ORCID: https://orcid.org/0000-0003-3816-3377)
- Deyi Zhao
- Weijun Chen (ORCID: https://orcid.org/0000-0003-1008-6584)
- Yao Sun (ORCID: https://orcid.org/0000-0002-9826-1756)
- Sichen Liu (ORCID: https://orcid.org/0009-0009-4961-359X)
- Zeyong Zhong
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Antimicrobial Resistance and Infection Control
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1186/s13756-025-01548-z
- Citations
- 6
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 10.30
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China