Mutational landscape and impact of clonal hematopoiesis of indeterminate potential in severe aortic valve stenosis
As the first study to evaluate a broad spectrum of CH driver mutations at all variant allele frequencies in the context of aortic valve stenosis, we found CHIP to be a frequent phenomenon and CH-driver mutations to be highly prevalent in patients with severe AVS. CHIP, other than DNMT3A-CHIP, was associated with increased mortality even after successful TAVR. The presence of CH driver mutations at low allele frequencies was not associated with mortality.
Authors
- Ansgar Ackerschott (ORCID: https://orcid.org/0000-0001-6473-2399)
- Malte Kelm (ORCID: https://orcid.org/0000-0003-0060-1052)
- Eicke Latz (ORCID: https://orcid.org/0000-0003-1488-5666)
- Benedikt Bartsch (ORCID: https://orcid.org/0000-0002-3126-221X)
- Claus Moritz Graef (ORCID: https://orcid.org/0000-0001-8573-3235)
- Stephan Baldus (ORCID: https://orcid.org/0000-0001-8259-1737)
- Baravan Al‐Kassou (ORCID: https://orcid.org/0000-0003-2967-6613)
- Muntadher Al Zaidi (ORCID: https://orcid.org/0000-0002-3534-3121)
- Sebastian Zimmer (ORCID: https://orcid.org/0000-0002-1531-2088)
- Raúl Nicolás Jamin (ORCID: https://orcid.org/0009-0003-2084-8463)
- Hannah Billig (ORCID: https://orcid.org/0009-0007-8609-1618)
- Jasmin Shamekhi (ORCID: https://orcid.org/0000-0002-5724-9814)
- Georg Nickenig (ORCID: https://orcid.org/0000-0003-2944-6033)
- Theresa Kleuker
Institutions
- University of Bonn (DE)
- University Hospital Bonn (DE)
- Düsseldorf University Hospital (DE)
- German Rheumatism Research Centre (DE)
- University Hospital Cologne (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Clinical Research in Cardiology
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1007/s00392-025-02658-9
- Citations
- 3
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 5.31
Funders
- Deutsche Forschungsgemeinschaft