Changes in Chronic Graft-versus-Host Disease Treatment Over Time: A 15-Years Survey Within Allogeneic Hematopoietic Stem Cell Transplant Centers in Germany, Austria, and Switzerland
The survey documents the effect of evidence and approval on clinical care with single agent prednisone representing the standard of care in 1<sup>st</sup>-line treatment while rux combined with steroids defines the new standard for 2<sup>nd</sup>-line treatment of cGVHD. ECP is used in case of contraindication for rux and both agents are also used in progressive onset cGVHD. In contrast, treatment of BOS and sclerotic cGVHD beyond 2<sup>nd</sup>-line treatment remains heterogeneous with new agents being integrated in the treatment landscape.
Authors
- Guido Kobbe (ORCID: https://orcid.org/0000-0002-9745-8813)
- Matthias Fante
- Daniel Wolff (ORCID: https://orcid.org/0000-0001-7015-3190)
- Julia Winkler (ORCID: https://orcid.org/0009-0000-0085-6480)
- Katharina Egger‐Heidrich (ORCID: https://orcid.org/0000-0002-0472-4335)
- Inken Hilgendorf (ORCID: https://orcid.org/0000-0003-2038-9730)
- Ánita Lawitschka (ORCID: https://orcid.org/0000-0002-4843-4735)
- Silke Heidenreich
- Olaf Penack (ORCID: https://orcid.org/0000-0003-4876-802X)
- Julia Marx
- Alexander Denk (ORCID: https://orcid.org/0000-0001-7599-9697)
- William Krüger (ORCID: https://orcid.org/0000-0003-3427-3632)
- Claudia Wehr (ORCID: https://orcid.org/0000-0002-5037-6175)
- Jochen J. Frietsch (ORCID: https://orcid.org/0000-0002-1476-8059)
- Gesine Bug (ORCID: https://orcid.org/0000-0003-2359-131X)
- Irene Teichert von Lüttichau
- Stefan Klein (ORCID: https://orcid.org/0000-0002-3351-6551)
- Lutz Peter Mueller (ORCID: https://orcid.org/0000-0002-3633-1309)
- Hildegard Greinix
- Joerg Halter
- Eva-Maria Wagner Drouet
- Darina Kodzhabasheva
Institutions
- Goethe University Frankfurt (DE)
- Universität Hamburg (DE)
- University of Freiburg (DE)
- Johannes Gutenberg University Mainz (DE)
- Medical University of Graz (AT)
- Heidelberg University (DE)
- Universitätsmedizin Greifswald (DE)
- University Hospital Heidelberg (DE)
- University Hospital of Basel (CH)
- University Hospital Regensburg (DE)
- Humboldt-Universität zu Berlin (DE)
- Universitätsklinikum Erlangen (DE)
- Düsseldorf University Hospital (DE)
- Klinik und Poliklinik für Kinder- und Jugendmedizin (DE)
- University Hospital Münster (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- St Anna Children's Hospital (AT)
- Universitätsklinikum Würzburg (DE)
- University Hospital Frankfurt (DE)
- Jena University Hospital (DE)
- St.-Johannes-Hospital Dortmund (DE)
- University Hospital in Halle (DE)
- University Hospital Carl Gustav Carus (DE)
- Heinrich Heine University Düsseldorf (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Transplantation and Cellular Therapy
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1016/j.jtct.2025.04.017
- Citations
- 2
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 3.54