The exercise-conditioned human serum and skeletal muscle cells secretome induce apoptosis in breast cancer cells
Both exercise-conditioned serum of breast cancer patients and skeletal myotubes secretome after mechanical loading can reduce the metabolic activity, promote cell toxicity and DNA damage, modulate the protein expression of crucial cell survival-regulating factors, and lead to apoptosis in breast cancer cells. These findings suggest that even after cancer diagnosis, exercise may exert beneficial effects additive to chemotherapy against breast cancer prognosis.
Authors
- Αnastassios Philippou (ORCID: https://orcid.org/0000-0003-0047-3003)
- Μαρία Παππά (ORCID: https://orcid.org/0000-0003-1296-0693)
- Michael Koutsilieris (ORCID: https://orcid.org/0000-0002-3340-9916)
- Athanasios Moustogiannis (ORCID: https://orcid.org/0000-0002-1441-4664)
- Αrgyro Papadopetraki (ORCID: https://orcid.org/0000-0002-4230-1835)
- Flora Zagouri (ORCID: https://orcid.org/0000-0001-7153-6556)
- Tatiana Giaskevits
- Μaria Maridaki (ORCID: https://orcid.org/0000-0003-3458-4633)
- Stavroula Droufakou
- Antonios Giannopoulos (ORCID: https://orcid.org/0000-0002-1033-7489)
Institutions
- English Institute of Sport (GB)
- National and Kapodistrian University of Athens (GR)
- Alexandra Hospital (GR)
- Athens Medical Center (GR)
- Frontier Science Foundation-Hellas (GR)
- IASO General Hospital (GR)
Publication Details
- Journal
- Journal of sport and health science/Journal of Sport and Health Science
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1016/j.jshs.2025.101051
- Citations
- 1
- Primary Topic
- Cancer Risks and Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.05