Esophageal Epidermoid Metaplasia Treated With Endoscopic Submucosal Dissection

Esophageal epidermoid metaplasia (EEM) is a rare condition characterized by well-demarcated leukoplakia affecting the middle-to-distal esophagus. EEM commonly presents in middle-aged females with dysphagia and gastroesophageal reflux. EEM is thought to be associated with high-grade squamous dysplasia and squamous cell carcinoma. We report a case of a 63-year-old woman diagnosed with EEM after en bloc endoscopic submucosal dissection in a lesion initially reported as squamous dysplasia. The patient was initiated on a PPI with a 6-month follow-up showing no areas of squamous dysplasia or recurrent EEM with normal squamous mucosa on biopsy. The patient was symptom-free at 1-year follow-up.