Prognostic significance of cancer-associated fibroblasts and tumor-associated macrophages in the tongue squamous cell carcinoma and their correlation with tumor budding
These findings indicate that CAFs significantly influence the invasive characteristics of TSCC and are correlated with tumor budding and a poor prognosis. These results underscore the potential of targeting CAFs as a therapeutic strategy for improving OSCC outcome.
Authors
- Ken Miyabe (ORCID: https://orcid.org/0009-0006-0105-7027)
- Yukitsugu Kudo‐Asabe
- Akiteru Goto (ORCID: https://orcid.org/0000-0001-8776-9004)
- Michinobu Umakoshi
- Kei Koyama
- Masayuki Fukuda (ORCID: https://orcid.org/0000-0002-6103-7291)
- Yuki Oikawa
- Takechiyo Yamada (ORCID: https://orcid.org/0000-0002-6910-3265)
- Hiroshi Nanjo (ORCID: https://orcid.org/0000-0002-0885-7151)
- Makoto Yoshida (ORCID: https://orcid.org/0000-0001-9653-2332)
- Masamitsu Tanaka (ORCID: https://orcid.org/0000-0002-4823-9737)
- Kenichiro Suzuki
Institutions
- Akita University (JP)
- Akita University Hospital (JP)
Publication Details
- Journal
- Oral Oncology
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1016/j.oraloncology.2025.107295
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00