Tie-2 regulates endothelial morphological responses to shear stress by FOXO1-triggered autophagy
In conclusion, laminar fluid shear stress stimulates a novel Tie-2-FOXO1-autophagy signaling axis which is required for endothelial cell alignment. This represents a new mechanism by which Tie-2 contributes to vascular protection under laminar shear stress.
Authors
- Keisuke Shirakura (ORCID: https://orcid.org/0000-0002-9487-9495)
- Dietmar Vestweber (ORCID: https://orcid.org/0000-0002-3517-732X)
- Mana Ghanbarpour Houshangi
Institutions
- Max Planck Institute for Molecular Biomedicine (DE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1371/journal.pone.0322869
- Citations
- 3
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Max-Planck-Gesellschaft