Challenges in managing de novo diabetes in adults: A case report of a 47 year old male

Differentiating between type 1 and type 2 diabetes in adults can be challenging, particularly in cases that do not fit the classic presentation. Misclassification occurs in a significant proportion of patients, leading to delays in appropriate treatment. This case report describes a 47-year-old male with newly diagnosed diabetes, initially treated as type 2 diabetes but exhibiting progressive hyperglycemia, weight loss, and lack of response to oral medications. Further diagnostic testing, including C-peptide measurement and autoantibody screening, was crucial in refining the diagnosis. While the absence of anti-GAD and ICA antibodies ruled out autoimmune type 1 diabetes, the patient’s clinical presentation suggested an atypical form of diabetes requiring insulin therapy. This case underscores the importance of early differential diagnosis and highlights the role of continuous glucose monitoring, C-peptide testing, and antibody screening in guiding treatment decisions. A tailored approach to diabetes classification is essential to ensure timely initiation of appropriate therapy and prevent complications.

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Publication Details

Journal
Quality in Sport
Published
2025-05-05
DOI
https://doi.org/10.12775/qs.2025.41.60030
Primary Topic
Diabetes and associated disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Challenges in managing de novo diabetes in adults: A case report of a 47 year old male

Michał Bolek, Dominika Musialska, Bartosz Jagieła, Monika Fidyk et al.
Quality in Sport
Diabetes and associated disorders
article

Challenges in managing de novo diabetes in adults: A case report of a 47 year old male

Michał Bolek, Dominika Musialska, Bartosz Jagieła, Monika Fidyk, Aleksandra Kędzia, Magda Minkiewicz
article en

Abstract

Differentiating between type 1 and type 2 diabetes in adults can be challenging, particularly in cases that do not fit the classic presentation. Misclassification occurs in a significant proportion of patients, leading to delays in appropriate treatment. This case report describes a 47-year-old male with newly diagnosed diabetes, initially treated as type 2 diabetes but exhibiting progressive hyperglycemia, weight loss, and lack of response to oral medications. Further diagnostic testing, including C-peptide measurement and autoantibody screening, was crucial in refining the diagnosis. While the absence of anti-GAD and ICA antibodies ruled out autoimmune type 1 diabetes, the patient’s clinical presentation suggested an atypical form of diabetes requiring insulin therapy. This case underscores the importance of early differential diagnosis and highlights the role of continuous glucose monitoring, C-peptide testing, and antibody screening in guiding treatment decisions. A tailored approach to diabetes classification is essential to ensure timely initiation of appropriate therapy and prevent complications.

Quality in SportVol. 41
University of Wrocław (PL), Military Hospital (PK), Ludwik Hirszfeld Institute of Immunology and Experimental Therapy (PL)
Openalex Percentile: Top 89%
Diabetes and associated disorders
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