Modulation of senescent Lepr+ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression
In summary, our findings demonstrate that the leptin-Lepr signaling pathway promotes SSC senescence and exacerbates subchondral bone remodeling by activating the STAT3-FGF7 axis during OA progression, which may shed light on novel therapeutic strategies for OA.
Authors
- Li Ding (ORCID: https://orcid.org/0000-0001-9460-9201)
- Feng Yu (ORCID: https://orcid.org/0000-0003-3060-6233)
- Peilin Li (ORCID: https://orcid.org/0000-0002-9136-0882)
- Bo-Feng Yin
- Zhidong Zhao (ORCID: https://orcid.org/0000-0003-4672-7873)
- Heng Zhu (ORCID: https://orcid.org/0000-0002-8408-3821)
- Xiaotong Li (ORCID: https://orcid.org/0000-0001-8083-861X)
- Wenjing Zhang (ORCID: https://orcid.org/0000-0002-6694-6072)
- Lei Wang (ORCID: https://orcid.org/0000-0001-5492-5613)
- Zhi‐Ling Li
- Run-Xiang Xu
- Mingyu Liu (ORCID: https://orcid.org/0000-0001-9905-4399)
Institutions
- Anhui Medical University (CN)
- People's Liberation Army No. 150 Hospital (CN)
- Beijing Radiation Center (CN)
- Regenerative Medicine Institute (MX)
- Hebei University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1186/s13287-025-04342-1
- Citations
- 6
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 5.62
Funders
- National Key Research and Development Program of China