MicroRNA in intestinal tight junction regulation
MicroRNAs are essential molecules that regulate many biological functions, including intestinal tight junction (TJ) barriers. They regulate pro-inflammatory cytokines, which increase TJ permeability, and anti-inflammatory cytokines, which protect against inflammation and promote intestinal balance. This review explores the role of miRNAs in controlling inflammation and as a potential therapeutic approach for treating IBD and other intestinal disorders. Circulating miRNAs can also serve as biomarkers for intestinal damage and disease progression.
Authors
- Manmeet Rawat (ORCID: https://orcid.org/0000-0002-8325-3390)
- Yash Gupta (ORCID: https://orcid.org/0000-0003-3002-1315)
- Y. Thomas (ORCID: https://orcid.org/0000-0001-9011-8050)
- Prem Kumar Govindappa (ORCID: https://orcid.org/0000-0001-8069-234X)
Institutions
- University of Arizona (US)
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- npj gut and liver.
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1038/s44355-025-00022-2
- Citations
- 10
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 9.36
Funders
- University of Pennsylvania
- Pennsylvania State University
- National Institutes of Health
- Penn State College of Medicine