A well-characterized mechanistic model for exploring known or hypothesized T cell mediated drug induced liver injury: current capabilities and challenges for future predictivity
The DILIsym CD8<sup>+</sup> T cell sub-model is well-positioned for systematic testing to improve our understanding of CD8<sup>+</sup> T cell-mediated DILI. It is not yet predictive but indicates a promising direction to reduce DILI events in drug development.
Authors
- Zackary R. Kenz
- Lisl K.M. Shoda (ORCID: https://orcid.org/0000-0002-9310-0080)
- Christina Battista (ORCID: https://orcid.org/0000-0003-0469-0208)
- Lara Clemens
Institutions
- Simulations Plus (United States) (US)
Publication Details
- Journal
- Expert Opinion on Drug Metabolism & Toxicology
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1080/17425255.2025.2499551
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00