The role of plasma-derived small extracellular vesicles in pre-metastatic niche formation through modulation of macrophages in head and neck squamous cell carcinoma
sEVs from plasma of HNSCC patients transformed macrophages into metastasis-promoting TAMs and inhibited anti-tumour T cells, highlighting the potential of sEVs and TAMs as targets for therapeutic approaches.
Authors
- Barbara Wollenberg (ORCID: https://orcid.org/0000-0002-3062-459X)
- Franziska Oliveri (ORCID: https://orcid.org/0000-0002-3280-448X)
- Tsima Abou Kors (ORCID: https://orcid.org/0009-0005-8072-757X)
- Cornelia Brunner (ORCID: https://orcid.org/0000-0002-6456-5508)
- Ramin Lotfi (ORCID: https://orcid.org/0000-0002-5421-5280)
- Linda Hofmann (ORCID: https://orcid.org/0000-0002-0683-7659)
- Marie‐Nicole Theodoraki (ORCID: https://orcid.org/0000-0002-5491-1593)
- Diana Huber (ORCID: https://orcid.org/0009-0005-7931-4831)
- Sebastian Schmid (ORCID: https://orcid.org/0000-0002-1232-5350)
- Annika Betzler (ORCID: https://orcid.org/0000-0003-3261-7008)
- Thomas K. Hoffmann (ORCID: https://orcid.org/0000-0001-5127-3779)
- Lutz Schütt
Institutions
- Universität Ulm (DE)
- German Red Cross (DE)
- TUM Klinikum (DE)
- University Hospital Ulm (DE)
- Technische Hochschule Ulm (DE)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1038/s41416-025-03001-9
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe
- Universität Ulm