The SIK3-N783Y mutation is associated with the human natural short sleep trait

Sleep is an essential component of our daily life. A mutation in human salt induced kinase 3 (hSIK3), which is critical for regulating sleep duration and depth in rodents, is associated with natural short sleep (NSS), a condition characterized by reduced daily sleep duration in human subjects. This NSS hSIK3-N783Y mutation results in diminished kinase activity in vitro. In a mouse model, the presence of the NSS hSIK3-N783Y mutation leads to a decrease in sleep time and an increase in electroencephalogram delta power. At the phosphoproteomic level, the SIK3-N783Y mutation induces substantial changes predominantly at synaptic sites. Bioinformatic analysis has identified several sleep-related kinase alterations triggered by the SIK3-N783Y mutation, including changes in protein kinase A and mitogen-activated protein kinase. These findings underscore the conserved function of SIK3 as a critical gene in human sleep regulation and provide insights into the kinase regulatory network governing sleep.

Authors

Institutions

Publication Details

Journal
Proceedings of the National Academy of Sciences
Published
2025-05-05
DOI
https://doi.org/10.1073/pnas.2500356122
Citations
5
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
7.16

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

The SIK3-N783Y mutation is associated with the human natural short sleep trait

Y. T. Liang, Jun‐Yu Xu, Yating Chen, Hongmin Chen et al.
5 citations
Proceedings of the National Academy of Sciences
Sleep and Wakefulness Research
7.16
article

The SIK3-N783Y mutation is associated with the human natural short sleep trait

Y. T. Liang, Jun‐Yu Xu, Yating Chen, Hongmin Chen, Louis J. Ptáček, Xing Ye, Changqing Jin, Zheng Zhang, Zhou Xia, Zhu Shi, Chunyan Wan, Ying‐Hui Fu, Guangsen Shi
article en
5 citations

Abstract

Sleep is an essential component of our daily life. A mutation in human salt induced kinase 3 (hSIK3), which is critical for regulating sleep duration and depth in rodents, is associated with natural short sleep (NSS), a condition characterized by reduced daily sleep duration in human subjects. This NSS hSIK3-N783Y mutation results in diminished kinase activity in vitro. In a mouse model, the presence of the NSS hSIK3-N783Y mutation leads to a decrease in sleep time and an increase in electroencephalogram delta power. At the phosphoproteomic level, the SIK3-N783Y mutation induces substantial changes predominantly at synaptic sites. Bioinformatic analysis has identified several sleep-related kinase alterations triggered by the SIK3-N783Y mutation, including changes in protein kinase A and mitogen-activated protein kinase. These findings underscore the conserved function of SIK3 as a critical gene in human sleep regulation and provide insights into the kinase regulatory network governing sleep.

Proceedings of the National Academy of SciencesVol. 122(19)
Guangzhou University of Chinese Medicine (CN), Nanjing University of Chinese Medicine (CN), University of California, San Francisco (US), Chinese Academy of Sciences (CN), Shanghai Institute of Materia Medica (CN), University of Chinese Academy of Sciences (CN), Academia Sinica (TW)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 3%
Sleep and Wakefulness Research
7.16
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.