GluN3A Subunit Forms GluN3A-NMDAR and the Excitatory Glycine Receptor in Olfactory Sensory Neurons of Adult Rats

Experimental data presented in the article were obtained from isolated olfactory sensory neurons (OSNs) of adult Wistar rats. The aim of the study was to demonstrate, using in vivo fluorescent confocal microscopy and pharmacological analysis, whether the GluN3A subunit is localized in OSNs of adult animals. Analysis of the results revealed the presence of the GluN3A subunit in OSNs of adult rats as part of the excitatory glycine receptor and the GluN3A-containing N-methyl-D-aspartate receptor (GluN3A-NMDAR). In addition, typical NMDARs and non-NMDARs were also localized in OSNs. All these receptors can be located either in the same or in different receptor cells, reflecting the heterogeneity of OSNs in the olfactory epithelium.