Development and Validation of a Novel Prediction Model for Hearing Loss From Cisplatin Chemotherapy
PedsHEAR predicted SIOP Grade ≥2 HL in pediatric cisplatin-treated patients. This is the first validated model to successfully predict cisplatin-induced HL in a broadly representative population treated with diverse regimens across a range of treatment settings.
Authors
- Michael E. Scheurer (ORCID: https://orcid.org/0000-0002-8379-6088)
- Qi Nie
- Teresa Rushing (ORCID: https://orcid.org/0000-0002-3655-7957)
- Etan Orgel (ORCID: https://orcid.org/0000-0002-1487-6818)
- Bruce Carleton (ORCID: https://orcid.org/0000-0002-4485-4054)
- Colin J.D. Ross (ORCID: https://orcid.org/0000-0003-1476-7037)
- Joshua Millstein (ORCID: https://orcid.org/0000-0001-7961-8943)
- Austin L. Brown (ORCID: https://orcid.org/0000-0001-5802-5073)
- Beth Brooks
- Diana J. Moke (ORCID: https://orcid.org/0000-0002-5062-5709)
- Adam J. Esbenshade (ORCID: https://orcid.org/0000-0002-0154-4996)
- Shahrad R. Rassekh (ORCID: https://orcid.org/0000-0001-8005-2641)
- Victoria Mena (ORCID: https://orcid.org/0009-0006-3996-2284)
- Lillian Sung (ORCID: https://orcid.org/0000-0003-0951-3091)
- Kristin R. Knight (ORCID: https://orcid.org/0000-0002-5701-3537)
- Michael Wright (ORCID: https://orcid.org/0000-0003-0012-0857)
Institutions
- University of Southern California (US)
- Children's Hospital of Los Angeles (US)
- Kaiser Permanente (US)
- University of British Columbia (CA)
- University of Tennessee Health Science Center (US)
- Baylor College of Medicine (US)
- Hospital for Sick Children (CA)
- Texas Children's Hospital (US)
- BC Children's Hospital (CA)
- Doernbecher Children's Hospital (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1200/jco-24-01861
- Citations
- 1
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 1.46