Comparative evaluation of immunomodulatory cytokines for oncolytic therapy based on a high-efficient platform for oHSV1 reconstruction
Our findings underscore the need for rational cytokine selection in oHSV1-based immunotherapy. While IFN-γ increased immunogenic markers, its systemic toxicity and myeloid effects may limit benefit. GM-CSF exacerbated immune suppression in this context, whereas IL15Fu showed favorable immunostimulatory properties without detectable toxicity. These data support IL15Fu as a contextually promising payload for further evaluation in TNBC-targeted oncolytic virotherapy.
Authors
- Xinwei Huang (ORCID: https://orcid.org/0000-0002-8568-6261)
- Juan Tao (ORCID: https://orcid.org/0000-0001-6571-6649)
- Yujing Zou (ORCID: https://orcid.org/0000-0001-9969-1224)
- Jinyuan Yan (ORCID: https://orcid.org/0000-0002-3398-3459)
- Yingzheng Gao (ORCID: https://orcid.org/0000-0002-5638-7094)
- Pengfei Wang (ORCID: https://orcid.org/0000-0002-9886-6982)
- Zuqing Nie (ORCID: https://orcid.org/0000-0002-3016-5733)
- Changjing Wu
Institutions
- Kunming Medical University (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1186/s12985-025-02758-y
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Pennsylvania
- National Natural Science Foundation of China