Paired molecular profiling of malignant transformation of an epidermoid cyst for potential genetic drivers: illustrative case
To the authors' knowledge, this represents the first use of paired molecular profiling to link intracranial SCC to an EC precursor, enhancing precision of this rare diagnosis. Additionally, this case identifies specific genetic alterations associated with transformation, providing insight into the largely unknown mechanisms underlying MTEC. https://thejns.org/doi/10.3171/CASE24849.
Authors
- Rodas Asrat Kassu (ORCID: https://orcid.org/0000-0002-9035-3824)
- Amit Persad (ORCID: https://orcid.org/0000-0001-6139-5542)
- Paul M. Harary (ORCID: https://orcid.org/0000-0002-4683-2115)
- Daniel T. Chang (ORCID: https://orcid.org/0000-0003-2760-1554)
- Yusuke S. Hori (ORCID: https://orcid.org/0000-0001-9921-6810)
- Sara Coleman Emrich
- Jae‐Hyun Park (ORCID: https://orcid.org/0000-0002-9858-2592)
- Juan C. Fernandez‐Miranda
- Louisa Ustrzynski
- Armine Tayag
- Iris C. Gibbs (ORCID: https://orcid.org/0000-0002-2693-7980)
Institutions
- Stanford University (US)
Publication Details
- Journal
- Journal of Neurosurgery Case Lessons
- Published
- 2025-05-05
- DOI
- https://doi.org/10.3171/case24849
- Citations
- 1
- Primary Topic
- Teratomas and Epidermoid Cysts
- Type
- article
- Field-Weighted Citation Impact
- 2.01