[99mTc]Tc-antigranulocyte scintigraphy for prediction of bone marrow reserve prior to radioligand therapy in patients with metastatic castration resistant prostate cancer
[<sup>99m</sup>Tc]Tc-antigranulocyte scintigraphy may support the assessment of bone marrow reserve in patients with extensive bone metastases. Spatial mismatch was associated with no significant myelotoxicity, whereas high congruence may increase the risk. No fixed thresholds currently exist; thus, this method should be regarded as a supplementary tool in complex cases and future studies are needed to define the critical bone marrow volume.
Authors
- Lena M. Unterrainer
- Harun Ilhan (ORCID: https://orcid.org/0000-0003-0409-1942)
- Maximilian Scheifele
- Rudolf Alexander Werner (ORCID: https://orcid.org/0000-0003-3372-6046)
- Adrien Holzgreve (ORCID: https://orcid.org/0000-0002-9566-8438)
- Jozefina Casuscelli (ORCID: https://orcid.org/0000-0002-9899-1986)
- Marcus Unterrainer (ORCID: https://orcid.org/0000-0002-8238-1198)
- Franz Josef Gildehaus (ORCID: https://orcid.org/0000-0002-6830-1817)
- Astrid Delker
- Mathias J. Zacherl
- Sophie C. Kunte (ORCID: https://orcid.org/0009-0003-3175-952X)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- LMU Klinikum (DE)
- Ihre-Radiologen (DE)
- German Center for Infection Research (DE)
- Molecular Theranostics (United States) (US)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1007/s00259-025-07319-7
- Citations
- 4
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 5.44
Funders
- Deutsche Forschungsgemeinschaft