Physiologically-based pharmacokinetic modeling to predict the exposure and provide dosage regimens of adalimumab in patients with juvenile idiopathic arthritis
A PBPK model for adalimumab in pediatric patients with JIA was developed, providing a basis for personalized dosing regimens in this population.
Authors
- Liying Gong (ORCID: https://orcid.org/0000-0002-9569-8450)
- Qi Pei (ORCID: https://orcid.org/0000-0002-6711-4251)
- Yun Kuang (ORCID: https://orcid.org/0000-0002-2136-0350)
- Guoping Yang (ORCID: https://orcid.org/0000-0001-5930-586X)
- Yaxin Liu (ORCID: https://orcid.org/0000-0002-0981-5746)
- Jinyi Liu (ORCID: https://orcid.org/0000-0003-1803-7752)
Institutions
- Central South University (CN)
Publication Details
- Journal
- Expert Review of Clinical Pharmacology
- Published
- 2025-05-04
- DOI
- https://doi.org/10.1080/17512433.2025.2502366
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province