Reduced HLA-I Transcript Levels and Increased Abundance of a CD56dim NK Cell Signature Are Associated with Improved Survival in Lower-Grade Gliomas
Overall, our study unveils a potential role for deregulated HLA-I expression in modulating the clinical impact of glioma-infiltrating CD56<sup>dim</sup> NK cells. These findings lay the foundation for future in-depth experimental studies to investigate the underlying mechanisms.
Authors
- Alexander D. Barrow (ORCID: https://orcid.org/0000-0001-5833-0537)
- Yuhan Sun (ORCID: https://orcid.org/0009-0002-3510-5964)
- Alexandra Jane Corbett (ORCID: https://orcid.org/0000-0003-1618-4337)
- J.P. Vivian (ORCID: https://orcid.org/0000-0002-9400-4437)
- Riccardo Dolcetti (ORCID: https://orcid.org/0000-0003-1625-9853)
- Md. Abdullah‐Al‐Kamran Khan (ORCID: https://orcid.org/0000-0002-3484-6333)
- Alexander James Sedgwick (ORCID: https://orcid.org/0000-0002-8200-8967)
- Linda Peel
- Theo Mantamadiotis (ORCID: https://orcid.org/0000-0003-3971-5380)
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Peter MacCallum Cancer Centre (AU)
- Peter Doherty Institute (AU)
- St Vincents Institute of Medical Research (AU)
- Australian Catholic University (AU)
Publication Details
- Journal
- Cancers
- Published
- 2025-05-05
- DOI
- https://doi.org/10.3390/cancers17091570
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80