Gut Expansion of a Human Lupus Pathobiont is Associated With Autoantibody Production and T Cell Dysregulation
RG2 contributes to autoimmune activation, at least by inducing Treg apoptosis. The expansion of this pathobiont is promoted by host genetic factors and tryptophan metabolism. Thus, targeted RG2 depletion may improve disease outcomes in patients with lupus.
Authors
- Mansour Mohamadzadeh
- Josephine Brown (ORCID: https://orcid.org/0000-0002-2511-8756)
- Abigail Castellanos Garcia (ORCID: https://orcid.org/0000-0002-7359-5725)
- Seung‐Chul Choi (ORCID: https://orcid.org/0000-0001-6230-9087)
- Longhuan Ma (ORCID: https://orcid.org/0000-0002-1836-3462)
- Laurence Morel (ORCID: https://orcid.org/0000-0002-6622-1290)
- N. Six
- Gregg J. Silverman
Institutions
- The University of Texas at San Antonio Health Science Center (US)
- University of Florida (US)
- New York University (US)
Publication Details
- Journal
- ACR Open Rheumatology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/acr2.70033
- Citations
- 2
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- University of Texas Health Science Center at San Antonio
- National Institute of Allergy and Infectious Diseases