EFI Abstracts

mice exhibited increased levels of cytotoxic granules, further supporting the role of ERAP1 in modulating NK cell activity.Overall, our findings indicate that disrupting the inhibitory KIR-HLA-A/B/C and NKG2A-HLA-E axes through ERAP1 inhibition is an attractive therapeutic approach for haematological malignancies.

Publication Details

Journal
HLA
Published
2025-05-01
DOI
https://doi.org/10.1111/tan.70158
Primary Topic
Immune Cell Function and Interaction
Type
article
Field-Weighted Citation Impact
0.00

Funders

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EFI Abstracts

HLA
Immune Cell Function and Interaction
article

EFI Abstracts

article en

Abstract

mice exhibited increased levels of cytotoxic granules, further supporting the role of ERAP1 in modulating NK cell activity.Overall, our findings indicate that disrupting the inhibitory KIR-HLA-A/B/C and NKG2A-HLA-E axes through ERAP1 inhibition is an attractive therapeutic approach for haematological malignancies.

HLAVol. 105(S1)
Université de Lille, Université de Toulouse, Assistance publique-Hôpitaux de Paris
Openalex Percentile: Top 89%
Immune Cell Function and Interaction
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EFI Abstracts · HLA (2025) | TGRS Research Map | TGRS