Factors associated with hyperhomocysteinemia in relatively healthy adult males in northern Shaanxi, China: A cross-sectional study

The elevated level of homocysteine (Hcy) is considered to be a risk factor for cardiovascular diseases and many other diseases, and cardiovascular diseases occurs more frequently in men. The purpose of our study was to evaluate the factors associated with hyperhomocysteinemia (Hhcy) in relatively healthy adult males in northern Shaanxi. This is a cross-sectional study involving male participants who underwent health examinations at the Health Management Center of Yulin Hospital, the first affiliated Hospital of Xi'an Jiaotong University in 2023. Hhcy was defined as plasma homocysteine ≥15 mmol/L. The related factors of Hhcy were analyzed by univariate and multivariate logistic regression. A total of 728 adult males were enrolled, with a median age of 36 years, of whom 274 (37.6%) had Hhcy. Multivariate logistic regression analysis showed that height, methylenetetrahydrofolate reductase TT genotype (hereinafter referred to as TT genotype), uric acid, thyroid stimulating hormone and alpha fetoprotein were significantly associated with Hhcy. In this cross-sectional study, height, TT genotype, uric acid, thyroid stimulating hormone and alpha fetoprotein were significantly associated with Hhcy in relatively healthy adult males in northern Shaanxi.