The effect of esketamine on postoperative anxiety and depression in patients with thyroid cancer: A randomized, double-blind, placebo-controlled, parallel-group trial

Intravenous injection of 0.5 mg/kg esketamine during the induction period of general anesthesia can prevent and alleviate postoperative anxiety and depression in patients with thyroid cancer, and its mechanism may be related to increased mBDNF and 5-HT levels and reduced IGF-1 levels. At the same time, hemodynamics during anesthesia surgery are more stable.