Iron-Catalyzed P(O)–S Bond Formation through Cross-Dehydrogenative Coupling of Thiols with P(O)H Compounds
Abstract We herein report an iron(salan)-catalyzed cross-dehydrogenative coupling of thiols with P(O)H compounds for the efficient synthesis of a range of thiophosphates, thiophosphinates, and thiophosphinites. This mild and practical method employs environmentally benign air as terminal oxidant, and earth-abundant metal iron at a low loading as catalyst, and exhibits broad substrate scope and good functional group tolerance, which is applicable to bioactive molecule preparation.
Authors
- Yongyong Ji
- Lei Liu (ORCID: https://orcid.org/0000-0002-0839-373X)
- Gang Wang (ORCID: https://orcid.org/0000-0002-8407-6429)
- Hongbin Liu (ORCID: https://orcid.org/0000-0001-9011-1182)
- Di Song (ORCID: https://orcid.org/0000-0002-1894-5673)
- Bing Han (ORCID: https://orcid.org/0000-0003-0507-9742)
Institutions
- Academy of Medical Sciences (GB)
- Shandong University (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Synthesis
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1055/a-2600-4572
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province