Splice it hot: How nuclear PP2A B′η regulates splicing fidelity by targeting the heat-stressed spliceosome

Heat stress (HS) often triggers a burst of reactive oxygen species (ROS) in plant cells, disrupting plasma membrane homeostasis and causing irreversible oxidative damage, particularly to photosystems I and II, ultimately impairing plant growth and development.Agricultural crop production is highly vulnerable to temperature spikes, which can lead to catastrophic yield losses (Kan et al., 2023).Alternative splicing (AS), which regulates transcript abundance and increases proteome diversity, is an effective strategy used by plants to cope with various stresses, including HS.