Will adaptive deep brain stimulation for Parkinson’s disease become a real option soon? A Delphi consensus study
While conventional deep brain stimulation (cDBS) treatment delivers continuous electrical stimuli, new adaptive DBS (aDBS) technology provides dynamic symptom-related stimulation. Research data are promising, and devices are already available, but are we ready for it? We asked leading DBS experts worldwide (n = 21) to discuss a research agenda for aDBS research in the near future to allow full adoption. A 5-point Likert scale questionnaire, along with a Delphi method, was employed. In the next 10 years, aDBS will be clinical routine, but research is needed to define which patients would benefit more from the treatment; second, implantation and programming procedures should be simplified to allow actual generalized adoption; third, new adaptive algorithms, and the integration of aDBS paradigm with new technologies, will improve control of more complex symptoms. Since the next years will be crucial for aDBS implementation, the research should focus on improving precision and making programming procedures more accessible.
Authors
- Andrea A. Kühn (ORCID: https://orcid.org/0000-0002-4134-9060)
- Carmen Gasca‐Salas (ORCID: https://orcid.org/0000-0001-7411-8106)
- Veerle E. R. M. Visser-Vandewalle (ORCID: https://orcid.org/0000-0002-5274-7929)
- Raúl Martínez‐Fernández (ORCID: https://orcid.org/0000-0002-0305-013X)
- Alfons Schnitzler (ORCID: https://orcid.org/0000-0002-6414-7939)
- Jill L. Ostrem (ORCID: https://orcid.org/0000-0001-7018-9521)
- Philip A. Starr (ORCID: https://orcid.org/0000-0003-2733-4003)
- Natale Vincenzo Maiorana (ORCID: https://orcid.org/0000-0002-6547-6304)
- Jens Volkmann (ORCID: https://orcid.org/0000-0002-9570-593X)
- Patricia Limousin (ORCID: https://orcid.org/0000-0001-5668-5545)
- Emma Scelzo (ORCID: https://orcid.org/0000-0002-7504-3246)
- Alfonso A. Fasano (ORCID: https://orcid.org/0000-0001-5346-0180)
- Michael S. Okun (ORCID: https://orcid.org/0000-0002-6247-9358)
- Clement Hamani (ORCID: https://orcid.org/0000-0002-7586-2487)
- Sara Renata Francesca Marceglia (ORCID: https://orcid.org/0000-0002-0456-866X)
- Simon J Little (ORCID: https://orcid.org/0000-0001-6249-6230)
- Yasin Temel (ORCID: https://orcid.org/0000-0002-3589-5604)
- Tommaso Bocci (ORCID: https://orcid.org/0000-0001-8874-1070)
- Gerd Tinkhauser (ORCID: https://orcid.org/0000-0002-1954-1873)
- Alberto Priori (ORCID: https://orcid.org/0000-0002-1549-3851)
- Günther Deuschl (ORCID: https://orcid.org/0000-0002-4176-9196)
- Matteo Guidetti (ORCID: https://orcid.org/0000-0002-4562-009X)
- Andrés M. Lozano (ORCID: https://orcid.org/0000-0001-8257-3694)
- Serena Oliveri (ORCID: https://orcid.org/0000-0002-7185-4260)
- Lars Timmermann (ORCID: https://orcid.org/0000-0002-5301-3580)
- Joachim K. Krauss (ORCID: https://orcid.org/0000-0002-0675-9064)
- Marta De Pedro Del Álamo
Institutions
- University of Bern (CH)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- Philipps University of Marburg (DE)
- University of California, San Francisco (US)
- University of Cologne (DE)
- University of Toronto (CA)
- University of Milan (IT)
- Toronto Western Hospital (CA)
- University Hospital of Bern (CH)
- Instituto de Salud Carlos III (ES)
- German Center for Neurodegenerative Diseases (DE)
- Health Sciences Centre (CA)
- Christian-Albrechts-Universität zu Kiel (DE)
- University of Florida (US)
- Maastricht University (NL)
- Medizinische Hochschule Hannover (DE)
- Humboldt-Universität zu Berlin (DE)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- HM Hospitales (ES)
- University Hospital HM Puerta del Sur (ES)
- Universitätsklinikum Würzburg (DE)
- National Hospital for Neurology and Neurosurgery (GB)
- Bernstein Center for Computational Neuroscience Berlin (DE)
- University Hospital Cologne (DE)
- Neurological Surgery (US)
- International Neuromodulation Society (US)
- Krembil Research Institute
- Heinrich Heine University Düsseldorf (DE)
- University College London (GB)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1038/s41531-025-00974-5
- Citations
- 12
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 16.67
Funders
- National Science Foundation
- Teva Pharmaceutical Industries
- International Parkinson and Movement Disorder Society
- Boston Scientific Corporation
- Parkinson Alliance
- Parkinson's Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health
- Instituto de Salud Carlos III
- National Institute of Neurological Disorders and Stroke