CuH-Catalyzed Regio- and Stereoselective Hydroalkoxylation of Styrenes with Acetal-Based Peroxides
An oxygen-umpolung-enabled, copper-catalyzed hydroalkoxylation reaction of styrenes has been developed. The key to success lies with the CF3-substituted electron-deficient acetal-based peroxides, which enables the chemo-, regio-, and stereoselective net hydroalkoxylation of alkene π-bonds under the initiation by CuH species. The use of a chiral bisphosphine ligand further enables the delivery of enantioenriched chiral ethers with good enantiomeric ratios.
Authors
- Kosuke Yasui (ORCID: https://orcid.org/0000-0002-3906-8307)
- Koji Hirano (ORCID: https://orcid.org/0000-0001-9752-1985)
- Kyosuke Fujiwara
- Yuki Kojima
- Shōgo Nakamura (ORCID: https://orcid.org/0009-0003-6071-2755)
Institutions
- Center for Research and Interdisciplinarity (FR)
- Graduate School USA (US)
- The University of Osaka (JP)
Publication Details
- Journal
- ACS Catalysis
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1021/acscatal.5c02202
- Citations
- 4
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- Japan Society for the Promotion of Science
- Fusion Oriented REsearch for disruptive Science and Technology