Multi‐ancestry genome‐wide association study of topiramate's effects on heavy alcohol use
Although no loci reached genome-wide significance, the suggestive variants identified in the cross-ancestry meta-analysis are promising candidates for future investigation. Larger studies are needed to identify significant genetic predictors of topiramate response and advance precision medicine strategies for treating AUD.
Authors
- Amy C. Justice (ORCID: https://orcid.org/0000-0003-0139-5502)
- Christopher T. Rentsch (ORCID: https://orcid.org/0000-0002-1408-7907)
- Christal N. Davis (ORCID: https://orcid.org/0000-0003-3974-5598)
- Henry R. Kranzler (ORCID: https://orcid.org/0000-0002-1018-0450)
- Zeal Jinwala (ORCID: https://orcid.org/0009-0005-5062-0827)
Institutions
- Yale University (US)
- VA Connecticut Healthcare System (US)
- London School of Hygiene & Tropical Medicine (GB)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alcohol Clinical and Experimental Research
- Published
- 2025-05-05
- DOI
- https://doi.org/10.1111/acer.70069
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- VISN 4 Mental Illness Research, Education, and Clinical Center
- NIH Clinical Center